Evaluation of HLA-B51 frequency and its relationship with clinical findings in patients with Behçet’s disease: 4-year analysis in a single center

Abstract Background The clinical findings of Behçet’s disease (BD) differ according to the country and race investigated. most important genetic factor known in pathogenesis BD is HLA-B51, this positivity high countries on “Silk Road” where as frequent it Turkey. Although HLA B51 proven be Turkey, there are no studies area western Black sea demonstrating its relation demographic. We aimed investigate association HLA-B51 Turkish patients diagnosed having relationship between demographic patients. Results In descriptive, cross-sectional study, a convenience sample adults with was obtained from an outpatient clinic university hospital Turkey January 2018 2022. Patients were criteria International Study Group, patients’ sociodemographic characteristics recorded retrospectively. Demographic data frequency compared who HLA-B51-positive HLA-B51-negative. Sixty (55.6%) HLA-B51-positive. Oral ulceration, genital thrombophlebitis, family history found higher Erythema nodosum, papulopustular eruption, pathergy positivity, arthritis, ocular involvement less positivity. However, statistically significant differences HLA-B51-negative groups. Conclusions not diagnostic BD; however, may affect phenotypes. oral ulcerations, positive common could reach statistical significance.